The Importance of Optimal Thermal Ablation Margins in Colorectal Liver Metastases: A Systematic Review and Meta-Analysis of 21 Studies.

Cancers (Basel) · 2023 · PMC10741591 · PMID 38136351

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep -value > 0.05actually significant

more than 5 mm, but this result did not reach statistical significance (RR: 2.56; 95% CI: 0.95–6.89; p -value > 0.05).

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marginally non-significantp -value > 0.06so close (0.05 < p ≤ 0.1)

Funnel plot asymmetry evaluation using the Egger’s test revealed significant asymmetry (t = 3.58; p -value < 0.002), indicating potential publication bias, while Begg’s test yielded a marginally non-significant result (z = 1.87; p -value > 0.06), suggesting weaker evidence against funnel plot symmetry (Funnel plot in Supplementary Figure S1A ).

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