The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.

A strong trend towards an opposing genotype effect in male versus female LacZ B6/J Pde11a KO mice is also observed across the higher frequencies of theta power during REM ( Figure 5 K,L; three-way RM ANOVA for effect of genotype × sex: F(1,136) = 4.41, p = 0.051).

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