Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms.

Int J Mol Sci · 2023 · PMC10743753 · PMID 38139386

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

close-to-significantp = 0.07so close (0.05 < p ≤ 0.1)

This effect is notably amplified by olaparib, with significantly elevated γH2AX levels as demonstrated by Western blot and flow cytometry, further supported by close-to-significant immunofluorescence analyses ( p = 0.07).

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