Indenopyrene and Blue-Light Co-Exposure Impairs the Tightly Controlled Activation of Xenobiotic Metabolism in Retinal Pigment Epithelial Cells: A Mechanism for Synergistic Toxicity.

Int J Mol Sci · 2023 · PMC10744144 · PMID 38139215

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did not reach statistical significanceno p-value reported

Moreover, it seems to stimulate Nrf2 nuclear translocation 3 h post-exposure in response to HEV light exposure and to IcdP/HEV co-exposure (although the increase in Nrf2 nuclear levels did not reach statistical significance— Figure 3 b,f).

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may be significantno p-value reported

Our work raises the prospect that lifestyle and environmental pollution may be significant modulators of HEV toxicity in the retina. high-energy visible light (HEV; blue light) polycyclic aromatic hydrocarbons metabolism indenopyrene (IcdP) phototoxicity oxidative stress retinal pigment epithelial (RPE) cells aryl hydrocarbon receptor (AhR) nuclear factor erythroid-2 related factor-2 (Nrf2) Natural Sciences and Engineering Research Council RGPIN-2023-04598 Fonds de Recherche du Québec—Santé This work was supported by a grant from the Natural Sciences and Engineering Research Council (NSERC; RGPIN-2023-04598) to P.J.R.

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