Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022.

Molecules · 2023 · PMC10745639 · PMID 38138431

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a marked trendno p-value reported

In contrast, the number of cancer approvals did not exhibit a marked trend, respectively.

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an increasing trendno p-value reported

Currently, large pharma faces challenges in drug development, leading to an increasing trend in collaborative research and development initiatives.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.