Exogenous Klotho Extends Survival in COVID-19 Model Mice.

method) to the female mice cohort receiving Klotho through osmotic minipump, was highly significant ( p trend < 0.001).

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There was a clear trend in survival benefit for mice that received supplemental recombinant mouse Klotho versus the controls, whereas the trend in mice receiving recombinant human Klotho was weak, indicating protein sequence specificity for the beneficial effects of Klotho supplementation.

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