Decoding glycomics with a suite of methods for differential expression analysis.

Cell Rep Methods · 2023 · PMC10753297 · PMID 37992708

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highly significantno p-value reported

Applied to an example dataset of O -glycomics data of BCC samples and healthy controls 20 ( Figure 3 C), we not only found significant mean differences (sulfated/sialylated glycans upregulated; neutral/fucosylated glycans downregulated) but also one sequence, Neu5Acα2-3Galβ1-3(Galβ1-4GlcNAc6Sβ1-6)GalNAc, which exhibited a highly significant Levene’s test.

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did not reach statistical significanceno p-value reported

While sialyl-Tn did exhibit a moderate upregulation ( d combined = 0.3), this did not reach statistical significance (p adj = 0.68) ( Table S5 ).

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