Moreover, after TRPM7 was disrupted, it showed a trend consistent with OIP5-AS1 and CD147 , that is, the level of apoptosis was significantly increased, which was confirmed by apoptosis flow cytometry and western blot ( Figures 6I–L ). 3.7 OIP5-AS1/CD147/TRPM7 axis promotes apoptosis by impairing PI3K-Akt signaling Notably, the western blot results showed that the p-AKT protein level was significantly reduced, but there was no significant difference in AKT protein expression after si-OIP5-AS1 both in AGS and MKN-45 cells.
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OIP5-AS1/CD147/TRPM7 axis promotes gastric cancer metastasis by regulating apoptosis related PI3K-Akt signaling.
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