Additionally, minimum Feret's diameter analysis showed a trend for a decrease in large muscle fibres (50.1–60 and 60+threshold), while the percentage of medium size fibre (30.1–40 threshold) was significantly increased in SOL muscle ( Fig. 4 d).
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Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis.
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