p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells.

2 A ), exposure of differentiating primary preadipocytes to p53KO CM also led to an increased cell number relative to WT CM, although the effect was much milder than with 3T3-L1 and did not reach statistical significance ( SI Appendix , Fig.

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6 A , although there was a slight trend toward reduced expression of mature adipocyte genes in 3T3-L1 cells exposed to mutp53 CM when compared to p53KO CM, it was not significant.

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In contrast, we observed a highly significant increase in the induced expression of the proinflammatory genes Saa3 and Il6 when 3T3-L1 cells were differentiated in the presence of CM from mutp53-expressing WEA cells, relative to p53KO CM ( Fig. 6 B ).

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