Repetitive spreading depolarization induces gene expression changes related to synaptic plasticity and neuroprotective pathways.

Front Cell Neurosci · 2023 · PMC10757627 · PMID 38162001

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

did not reach statistical significancep -value = 0.09so close (0.05 < p ≤ 0.1)

The difference between the contralateral and remote sites for NR4A1 did not reach statistical significance ( p -value = 0.09) and EGR2 did not show differential expression across regions ( Supplementary Figure 3 ). 4 Discussion This study is the first unbiased analysis of whole transcriptome changes in healthy brain tissue following repetitive spreading depolarization (SD).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.