Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility in <i>Scn2a ^K1422E</i> mice.

The above data suggest that ovarian sex hormones do not significantly contribute to flurothyl seizure thresholds in WT or Scn2a E/+ mice. Scn2a E/+ females that underwent sham surgery had a distribution that did not reach statistical significance for non-unimodality, although it was still significantly different from WT controls as determined by Kolmogorov-Smirnov test comparing cumulative distributions ( Figure 1B , P= 0.0218).

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