Recent systematic reviews investigating patients undergoing preoperative treatment with iron monotherapy compared to placebo, SoC, or no intervention showed a risk reduction regarding allogenic blood transfusion [ 12 – 14 ], of which two meta-analyses did not reach statistical significance [ 13 , 14 ] (e.g., optimal information size was not reached in review by Ng et al.).
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Reported outcomes in patients with iron deficiency or iron deficiency anemia undergoing major surgery: a systematic review of outcomes.
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