Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD).

Hum Vaccin Immunother · 2023 · PMC10760504 · PMID 37932241

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a marginal trendno p-value reported

CpG addition to alum (AP or AH) resulted in a marginal trend of improved pNTs in stressed samples only, yet did not impact the storage stability profiles of IVX-411.

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showed a trendno p-value reported

On the other hand, in mice administered stressed IVX-411 samples (37°C, 2 weeks), the same CpG + alum samples showed a trend toward improved neutralization titers (albeit statistically insignificant due high variability).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.