An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants.

After BA.5 challenge, all vaccinations led to remarkable (10 1.9 - to 10 5.9 -fold) reductions in virus titers relative to mock-immunization, although the difference in virus titers between mock-immunized mice and mice immunized with the ancestral-type vaccine followed by the bivalent vaccine did not reach statistical significance (Fig. 6g ).

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