Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.

Mol Neurodegener · 2024 · PMC10763080 · PMID 38172904

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closest p · 0.0× alpha

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highly significantP < 1.5×10 -250actually significant

The loci at chromosome 6 at the TREM2 locus, in cis, and chromosome 11 at MS4A locus, showed highly significant association ( P < 1.5×10 -250 ; Table S 4 ) in plasma, indicating shared genetic regulation between CSF and plasma.

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did not reach statistical significanceP =0.05actually significant

After confirming a successful silencing of TGFBR2 by using two independent shRNAs (shTGFBR2_B: ~42% decrease, P <0.0001; shTGFBR2_D: ~57% decrease, P =0.001), we saw a trend in lower intracellular TREM2 levels, although it did not reach statistical significance (shTGFBR2_B: ~16% decrease, P =0.05; shTGFBR2_D: ~19% decrease, P =0.09; Fig. 4 E middle panel, Fig.

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