Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth.

Effect of smoking on abdominal aortic aneurysm growth The UKAGS cohort is phenotypically similar to other AAA growth cohorts in terms of the effect of smoking, as evidenced by a highly significant faster AAA growth rate observed in current smokers compared with the ‘other’ smoking status group that included non-smokers and ex-smokers (+0.350 mm/year, P < 0.001, total number = 3663, unknown smoking status = 7), before adjusting for other factors.

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The other ACE inhibitors, ARBs, diuretics, and antiplatelets that did not reach statistical significance in this analysis showed the same direction of effect.

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