Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure.

Front Cardiovasc Med · 2023 · PMC10766701 · PMID 38188257

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However, at 4 weeks post TAC, the Trp53inp2-cKO mice demonstrated marked heart failure with significantly reduced ejection fraction ( Figure 2B ) and fraction shortening ( Figure 2C ) while the control mice only showed a trend in reduced cardiac function at more modest scale.

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