Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.

Neuropsychol Rev · 2023 · PMC10770217 · PMID 36057684

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did not reach statistical significanceno p-value reported

Hence, the lack of control for APOE ɛ4 status might help account for the contradictory findings from empirical studies on cognition of first-degree relatives of LOAD-affected individuals previously noted in the introduction, and if factored in to analyses of cognitive domains, could potentially paint a different picture with regard to the domains that did not reach statistical significance.

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