Early left ventricular microvascular dysfunction in diabetic pigs: a longitudinal quantitative myocardial perfusion CMR study.

Regarding perfusion reserve function, both MPRI and MPR showed a decreasing trend with the progression of disease duration (MPRI, P = 0.001; MPR, P = 0.042), with high consistency (r = 0.551, P < 0.001).

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Because the LV GPS-L, LV remodeling index, and MPR had no significant changes in the early stage, but showed a trend of gradual deterioration, the time sequence of injury/dysfunction was approximated, and no obvious causal relationship was found.

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