FSHD muscle shows perturbation in fibroadipogenic progenitor cells, mitochondrial function and alternative splicing independently of inflammation.

Hum Mol Genet · 2024 · PMC10772042 · PMID 37856562

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hedged sentences

0.0000

closest p · 0.0× alpha

0.0520

boldest claim

The sentences

highly significantP = 1.4 × 10 −16actually significant

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).

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approached significanceP = 0.052so close (0.05 < p ≤ 0.1)

Strikingly, 6/7 datasets demonstrated significant up-regulation of FAP gene expression in FSHD samples compared to controls, and the seventh approached significance ( P = 0.052) ( Fig. 2C ).

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