Isolated depletion of CD8 + cells compromises survival of WT B16 - FL mice, but the effect did not reach statistical significance, while survival of WT B16-FL mice with isolated depletion of NK cells is significantly lower than the untreated WT B16-FL mice ( Figures 3 F and S3 C).
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FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis.
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We detected highly significant and correlated relationship between DCs and activated Tregs in merged group analysis, but no or inverse correlation with activated Th ( Figure 2 D).