Better PS (HR = 0.043, 95% CI 0.014-0.136, P < 0.001) was independently associated with longer BM-related OS in multivariable analysis carried out for the ALK-BPI variables, whereas sex (HR = 0.61, 95% CI 0.35-1.06, P = 0.082) and primary brain metastatic disease (HR = 0.59, 95% CI 0.33-1.07, P = 0.084) showed a strong trend towards longer OS.
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Validation of the ALK-Brain Prognostic Index for patients with ALK-rearranged lung cancer and brain metastases.
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The sentences
Variables that were statistically significant, marginally significant, and clinically important were included in the multivariate analysis.