Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms.

Alzheimers Dement (Amst) · 2024 · PMC10776830 · PMID 38213949

Europe PMC DOI

hedged sentences

0.0048

closest p · 0.1× alpha

0.0540

boldest claim

The sentences

highly significantp = 4.8 × 10 −3actually significant

Likewise, the increase of NfL within each group from baseline to 90 months was also highly significant using NfL z‐scores (AD: p = 4.8 × 10 −3 , controls: p = 3.6 × 10 −11 ).

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showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

While a C+T PRS with a single p ‐value of 1 only showed a trend ( p = 0.054) in predicting AD diagnosis combined with baseline NfL, we found a highly significant predictive effect for AD diagnosis for PRS‐CS combined with baseline NfL.

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