While no obvious trends in the ADAMTSs/TIMP‐3 balance were observed in the current study, we found a clear trend that rapamycin blunts while 3‐MA promotes MMPs/TIMP‐1 imbalance.
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Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation.
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