Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection.

Notably, HLCZ01 cells inoculated with HBV showed a trend of steadily increasing HBV DNA and cccDNA content as the duration of infection increased, whereas HepG2-NTCP cells did not seem to be capable of maintaining the cccDNA pool for a long time ( Fig. 3B and E ).

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The HLCZ01 cells reached the highest infection efficiency at a DMSO concentration of 2.5%, after which the infection efficiency showed a decreasing trend, probably because the DMSO concentration reached a level that affected the cellular activity of HLCZ01 cells ( Fig. 2F ).

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