Adipose retinol saturase is regulated by β-adrenergic signaling and its deletion impairs lipolysis in adipocytes and acute cold tolerance in mice.

Enriched KEGG pathways among upregulated genes did not reach statistical significance, downregulated genes clustered, among others, to thermogenesis and oxidative phosphorylation ( Figure 5 B).

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Very little pathway enrichment was detected in negatively correlating genes, contrasted by highly significant clustering of positively correlating genes to KEGG pathways like oxidative phosphorylation and thermogenesis ( Figure 5 G).

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