A meta-analysis of Boolean network models reveals design principles of gene regulatory networks.

Albeit weakly significant but opposing differences for k = 3 (two-tailed Wilcoxon signed-rank test; P = 0.003) and k = 4 ( P = 0.004), we did not find any support for the hypothesis that either the master regulator or the intermediate regulator in a FFL is generally more important.

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Many of the trends and properties we identified are highly significant and consistent, which means they likely reflect true biological qualities of regulatory networks.

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