A new advanced cellular model of functional cholinergic-like neurons developed by reprogramming the human SH-SY5Y neuroblastoma cell line.

Data showed that over this culture period, the action potential firing frequency and the ability of cells to generate multiple action potentials showed a decreasing trend (Supplementary Fig.

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Moreover, cells in 3D cultures showed a trend to have more hyperpolarized resting membrane potentials (Fig. 1E ) and higher action potential firing frequencies compared to 2D cultures (Fig. 1F, G ).

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