showed a trendP = 0.13
Similarly, in the second revision of the international staging system (R2-ISS) which utilized 15 pooled clinical trials for model building, while t(14;16) showed a trend towards a shorter PFS, it was not statistically significant (HR 1.15 [95% CI, 0.96 to 1.37], P = 0.13) which could have potentially been impacted by the heterogeneity of the dataset and the therapies received [ 12 ].