Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs.

Inorg Chem Front · 2024 · PMC10790623 · PMID 38235273

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did not reach statistical significanceno p-value reported

6 , CisPt-GemCarb-C 5 Mal displayed anticancer activity similar to cisplatin, which both did not reach statistical significance compared to solvent control.

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highly significantno p-value reported

CarboPt-GemSucc-C 5 Mal revealed strong and highly significant anticancer activity against the carboplatin-resistant CT26 tumors ( Fig. 9C ), which resulted in significantly prolonged overall survival of the animals from ∼20 days in the solvent control to ∼40 days ( Fig. 9D ).

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