Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.

10b ), showing a nonsignificant trend to decreased VGLUT1/VGAT ratio after EEdis ( Supplementary Fig. 10b ).

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Moreover, although the increase in dendritic span and complexity with EE did not reach statistical significance, it nonetheless contributed to an overall improvement in the connectivity repertoire of the neuronal network.

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