Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume.

81 Another study comparing 2 mL of a mAb given over 5 seconds versus 15 seconds also reported lower pain scores with slower injections, although the differences did not reach statistical significance. 82 In a recent clinical feasibility study with 32 healthy volunteers, no clinically (≥10 mm on a visual analog scale) or statistically significant difference in injection pain was found between 5 mL, 4.1-minute and 10 mL, 8.2-minute injections at a constant rate of 20 μl/s. 83 Higher flow rate and

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