With respect to genetic causes of critical COVID-19, we observed a significant trend towards enrichment of very rare missense variants in the type I IFN signaling pathway in our cohort when adjusted for ancestry PCs and compared to a set of genes not associated with viral immunity but with similar size and constraint metrics.
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Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19.
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