We found a highly significant correlation between estradiol change ( p = 0.006), or PgR change ( p = 0.004) and Ki-67 change in non-obese women, as opposed to obese women, where neither estradiol change ( p = 0.422), nor PgR change ( p = 0.604), correlated with Ki-67 absolute change.
Tissue biomarker changes Although the median decrease in Ki-67 change in non-obese participants was similar among the three dosing regimens, the median reduction of 4% in Ki67 in the TIW dose schedule in obese women was less than the 8% median reduction in the QD arm which was marginally significant ( p = 0.02).
A dose-response decrease in SHBG was observed in favor of the TIW dose as opposed to the stronger decrease with the standard dose, mainly in obese women, while the difference between dose schedules did not reach statistical significance in non-obese subjects.