Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction.

C4A4-HNE showed a trend towards patients with mild disease having higher levels of the biomarker, with a dose-dependent decrease from patients with mild to severe endoscopic disease (ng/ml [IQR]: 28.2 [21.5, 28.2] vs. 24.6 [21.9, 24.7] vs. 23.3 [14.6, 28.8]) (Fig. 5 A, Supplementary Table S4 ).

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