Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease.

Front Immunol · 2023 · PMC10798041 · PMID 38250073

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a clear trendno p-value reported

In addition to Th1, Th2, and Th17 cells, we compared other CD4 + T cell subsets and found that there were no significant differences between HSAT patients and other groups in the levels of regulatory T cells (Treg; CD4 + CD25 + CD127 - ), T-follicular helper (Tfh; CD4 + CXCR5 + CD45RA - ), or T-follicular regulatory (Tfr; CD4 + CXCR5 + CD45RA - CD25 + CD127 - ) cells in circulation, though there was a clear trend toward decreased Tfh and increased Tfr in HSAT patients.

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failed to reach significanceno p-value reported

Similar trends were observed for IL-8 (CXCL8) and MIP-3a ( Figures 3G, H ), but failed to reach significance for either group. 3.2.4.

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