The traces obtained from these experiments contained sufficient kinetic information to determine the rate constants of the fluorescent probe at each temperature tested: as expected, the rates of probe’s association and dissociation kinetics were temperature-dependent, with a clear trend towards faster binding with increasing temperatures (Supplementary Table S1 ).
← all excerpts
A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition.
1
—
—