Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology burden.

However, the results showed a trend for the amygdala-predominant LBD cases to have lower average logSD 50 /mg values than the other groups in all brain areas where αSyn positivity was detected (medulla oblongata, substantia nigra, basal forebrain, cingulate gyrus, and temporal cortex), except in the amygdala, where the values were in the brainstem cases’ range (Fig. 3 a).

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