Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes.

Front Genet · 2023 · PMC10800577 · PMID 38259618

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nominally significantno p-value reported

Initially, we used the fast epistatic analysis method, BOOST ( Wan et al., 2010 ), on the SNPs located in genes and their regulatory regions to identify the most relevant SNPs and then used the standard epistatic analysis method on nominally significant epistatic SNP-SNP combinations to generate OR for GIs (Steps 1-6 in Figure 2 ).

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