Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression.

Front Immunol · 2023 · PMC10800801 · PMID 38259497

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0680

boldest claim

The sentences

highly significantP < 0.001actually significant

However, in apolipoprotein ε4 carriers, the MMSE declined, unlike in non-carriers, and the interaction effect (intervention × ε4 genotype) was highly significant (P < 0.001).

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a suggestive trendP=0.068so close (0.05 < p ≤ 0.1)

However, Neflamapimod treatment led to significantly reduced cerebrospinal fluid (CSF) levels compared to placebo, particularly in T-tau [difference (95% CI): -18.8 (-35.8, -1.8); P=0.031] and p-tau181 [-2.0 (-3.6, -0.5); P=0.012], with a suggestive trend for neurogranin [-21.0 (-43.6, 1.6); P=0.068].

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