Role of Gut Microbiota in Statin-Associated New-Onset Diabetes-A Cross-Sectional and Prospective Analysis of the FINRISK 2002 Cohort.

Our observations that statin use associated with a compositionally differing gut microbiota and was approaching significance in its association with higher alpha-diversity, are in line with previous findings, although it is important to note that that our results for beta-diversity might have been influenced by heterogenous dispersion of sample variances between statin users and nonusers. 1 , 20 , 48 , 49 Higher richness and diversity of the gut microbiota has been associated inversely with BMI and triglyceride levels as well as positively with HDL-cholesterol in a cohort of 893 individuals. 50 However, on the species level our study gives mixed results between beneficial and detrimental taxa.

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