Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non-small cell lung cancer.

As expected, based on the results that showed higher 5hmC levels over the T-cell inflamed GEP genes for responders relative to non-responders ( figure 5F ), a trend separating the two groups in terms of overall survival was observed, however it did not reach statistical significance with a p value of 0.11 in this smaller subset of patients ( online supplemental figure 3 ).

also in 111,027 other papers