Short-course neoadjuvant radiotherapy combined with chemotherapy and toripalimab for locally advanced esophageal squamous cell carcinoma (SCALE-1): a single-arm phase Ib clinical trial.

Tumors with a pCR showed additional higher levels of CD45 + , T-cell and cytotoxic cell infiltration (p < 0.05) ( figure 4C ), and an increasing trend of CD8 + T cells (p = 0.078) ( online supplemental appendix figure 8C ).

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While the difference did not reach statistical significance, there was a trend toward increased body weight in patients undergoing surgery after 8 weeks (p=0.198) ( online supplemental appendix figure 4 ).

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