As shown in Figure 4 , the fasting glucose ( O, U ) and insulin ( P, V ) levels in dox-fed Tg- AT-hA2 ;m A2 +/+ mice were slightly elevated compared to chow-fed Tg- AT-hA2 ;m A2 +/+ mice in both sexes, but this did not reach statistical significance.
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Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction.
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While there was a decreasing trend in male dox-fed Tg- AT-hA2 ;m A2 +/+ mice compared to chow-fed Tg- AT-hA2 ;m A2 +/+ mice, it did not reach statistical significance ( Figure 4 Q).