A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease.

Alzheimers Res Ther · 2024 · PMC10809445 · PMID 38273408

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a nonsignificant trendno p-value reported

A nonsignificant trend towards a treatment difference was observed for CT1812 relative to placebo in brain volume for the composite of brain regions.

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nominally significantno p-value reported

Composite region volumetric MRI revealed a trend towards tissue preservation in participants treated with either dose of CT1812, and nominally significant differences with both doses of CT1812 compared to placebo were found in the pericentral, prefrontal, and hippocampal cortices.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.