Effects of polyphenolic maqui (<i>Aristotelia chilensis</i>) extract on the inhibition of NLRP3 inflammasome and activation of mast cells in a mouse model of Crohn's disease-like colitis.

After treatment with maqui extract, both post- and pre-Treatment groups, showed a weak trend to down-regulated immune + -NF-кB staining and intensity of the cytosolic NF-кB staining in epithelial cells ( Figures 4C, D ), which was not statistically significant ( Figure 4E ).

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Notably, this difference did not reach statistical significance ( Figure 6E ).

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The MC count in colon tissue from the pre-Treatment group was similar to the control (35 ± 13.9) and even in the post-Treatment group the total number of MC was lower than the corresponding controls (22 ± 1.2 vs 34 ± 9, respectively); albeit this failed to reach significance ( Figure 7A ).

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