Within muscle-invasive cancers, the TROP2/EpCAM ratio marginally changed from pT2 (3.7 ± 2) to pT3 (3.8 ± 1.9) and pT4 (3.9 ± 1.9) cancers, but these differences did not reach statistical significance (p=0.3).
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Loss of TROP2 and epithelial cell adhesion molecule expression is linked to grade progression in pTa but unrelated to disease outcome in pT2-4 urothelial bladder carcinomas.
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