DISC1 and reelin interact to alter cognition, inhibition, and neurogenesis in a novel mouse model of schizophrenia.

There was also a trend toward differences in category 3 cells, and while it failed to reach significance [ F (3,18) = 3.141, p = 0.057], the group effect size (Cohen’s f = 0.7262) suggests that the lower number of category 3 cells in HRM/DISC1 hippocampi may be of interest. 2.7 Reduced dendritic spine density in HRM/DISC1 hippocampal dentate granule cells To further investigate the effects of reelin and DISC1 disruption on dendritic spines, we used Golgi-Cox staining to visualize a subset of neurons and counted dendritic spines in dentate granule cells (DGC) and hippocampal pyramidal cells (HPC) ( Figure 8A ).

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While a clear trend in performance emerged, the individual performance of DISC1 and HRM/DISC1 mice was more variable compared to WT and HRM groups.

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