Prognostic Impact of Serum β₂-Microglobulin Levels in Hodgkin Lymphoma Treated with ABVD or Equivalent Regimens: A Comprehensive Analysis of 915 Patients.

With respect to potential biological prognostic factors, highly significant correlations of moderate magnitude were observed between sβ 2 m and serum soluble CD30, serum interleukin-10 and serum ferritin ( p < 0.001 but Spearman’s rho 0.333–0.455), as summarized in Table 2 .

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The best cutoff was set at 2.0 mg/Land resulted in a marginally significant prediction, with 10-year FFP rates of 74% versus 64% ( p = 0.09, Figure 1 F).

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Similarly to the univariate results, sβ 2 m levels > 2.0 mg/L were an independent adverse prognostic factor of borderline significance in the multivariate analysis of patients with advanced stages, including all the IPS factors ( Table 4 ; see also footnote) along with stage IV, lymphopenia and leukocytosis (protective!!) (hazard ratio (HR) 1.44, 95% CI 0.94–2.21, and p = 0.098; Table 4 ).

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Serum β 2 m levels were the only independent predictor of HLSS, albeit of marginal significance, but had no effect on OS.

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